GLP-1R/CRE Luciferase Reporter HEK293 Cell Line is an engineered HEK293 cell line expressing firefly luciferase under the control of cAMP response element (CRE), and human GLP-1R (Glucagon-like peptide 1 receptor
Description
GLP-1R/CRE Luciferase Reporter HEK293 Cell Line is an engineered HEK293 cell line expressing firefly luciferase under the control of cAMP response element (CRE), and human GLP-1R (Glucagon-like peptide 1 receptor; accession number BC113493). Activation of GLP-1R in these cells can be monitored by measuring luciferase activity.
The functionality of GLP-1R/CRE Luciferase Reporter HEK293 Cell Line was validated in dose-response assays using the peptide agonists Glucagon-like peptide 1 (7-37), Exendin-4, Lixisenatide, GLP-1 moiety from dulaglutide, Semaglutide, Tirzepatide and Retatrutide. This cell line has also been validated in a dose-response assay using a small molecule agonist, Danuglipron. GLP-1R/CRE Luciferase Reporter HEK293 Cell Line responds to agonists by inducing luciferase activity in a dose-dependent manner.
GLP-1R/CRE Luciferase Reporter HEK293 Cell Line
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Figure 1. Illustration of mechanism of action in the GLP-1R/CRE Luciferase Reporter HEK293 Cell Line.
Purchase of this cell line is for research purposes only; commercial use requires a separate license. View the full terms and conditions.
●Synonyms
Glucagon-like peptide 1 receptor cell line, GLP-1 cells, GLP-1-R cell line, GLP-1R cells, glucagon like peptide 1 receptor cells
●Product Data Gallery
Cell surface expression of GLP-1R in GLP-1R/CRE Luciferase Reporter HEK293 cells.
Dose response of GLP-1 (7-37) and GIP in GLP-1R/CRE Luciferase Reporter HEK293 cells
Dose response of Exendin-4 in GLP-1R/CRE Luciferase Reporter HEK293 cells
Dose response of Lixisenatide in GLP-1R/CRE Luciferase Reporter HEK293 cells
Dose response of GLP-1 Moiety from Dulaglutide in GLP-1R/CRE Luciferase Reporter HEK293 cells
Dose response of Semaglutide in GLP-1R/CRE Luciferase Reporter HEK293 cells
Dose response of Tirzepatide, a dual GLP-1R and GIPR agonist, in GLP-1R/CRE Luciferase Reporter HEK293 cells
Dose response curve of GLP-1R/CRE Luciferase Reporter HEK293 Cell Line to Retatrutide, a triple agonist peptide of GLP-1R, GIPR, and GCGR
Dose response curve of GLP-1R/CRE Luciferase Reporter HEK293 Cell Line to Danuglipron, a non-peptide agonist of GLP-1R.
Response of GLP-1R/CRE Luciferase Reporter HEK293 cells to GLP-1 (7-37) shows reduced peptide stability in the presence of Fetal Bovine Serum (FBS)
Response of GLP-1R/CRE Luciferase Reporter HEK293 Cell Line to Danuglipron is stable in the presence and absence of FBS.
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